Endocrine Abstracts

Type 2 diabetes mellitus is a heterogeneous disease with multiple pathophysiological pathways contributing to hyperglycemia, and also resulting in a variable clinical picture. Thus, individualization of hypoglycemic therapy is a mainstay of current clinical guidelines. Several factors should be considered for a given treatment choice. These include the characteristics related to a given medication (efficacy, hypoglycemia, effect on weight, other safety issues, the mechanism of...

There are different activities related to health care that are currently generating a large amount of data. Real-world evidence studies are becoming an important source of information that complements the one produced through other sources of evidence. On top of this, current knowledge in the field of massive data analysis allows processing of these data to produce relevant information that will eventually help clinicians in many aspects of their daily practice, especially reg...

Objectives: To evaluate the efficacy, safety and patient’s pain perception of percutaneous ethanol injection treatment (PEIT) as an alternative to surgery in symptomatic thyroid cysts.Patients and methods: Thirty consecutive patients (mean age: 46±10 years; 82% women) with symptomatic thyroid cysts relapsed after drainage were included. In all cases, cytology prior to treatment, maximum cyst diameter and volume were determined. PEIT was conduct...

Introduction: Follicular tumours of the thyroid gland include benign follicular adenomas, follicular carcinomas and the follicular variant of papillary carcinoma. Although, molecular markers are a promising area of research to differentiate thyroid neoplasms, there is ample room for improvement in the research and clinical applications in this field. Furthermore, the final diagnosis requires thyroid lobectomy. The present study examined whether a differential protein expressio...

Introduction: MicroRNAs (miRNAs) are short non-coding RNAs that regulate translation or degradation of target mRNAs. Therefore, miRNAs control gene expression in many biological processes, including proliferation, apoptosis, and differentiation. Deregulation of miRNAs expression is an important contributor to tumour development and progression. Even though several genetic and epigenetic lesions have been identified in human thyroid cancer, particularly in the papillary histoty...

Introduction: The presence and type of atherosclerotic plaque is associated with future cardiovascular events (CVE). We previously described that increased frequency of plaques is associated with specific features in type 1 diabetes. The aim of the present study was to investigate the characteristics of atherosclerotic plaques in patients with type 1 diabetes mellitus (T1D).Methods: A cross-sectional study of 174 subjects with carotid atherosclerotic pla...

Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients with and without diabetes mellitus (DM). Traditional cardiovascular risk factors fail to fully account for the increase in cardiovascular risk in these patients. The NEFRONA study is a large, multicentre, prospective, observational study that evaluated atheromatous disease (AD) in the carotid and femoral territories in a large cohort of Spanish CKD ...

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures. Anti-diabetic oral agents and insulin may also impact on fracture risk. There is however scarce data available on the effect of such therapies combined as usually prescribed in real-life practice conditions.Objectives: The objective of this study was to compare the risk of fracture among T2DM patients who are users of different antidiabetic treatments...

Background: Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR).Subjects and methods: This was a two-center, cross-sectional study in patients diagnosed with T1DM with and without DR. Su...

Background: An association of pregnancy outcomes with subclinical hypothyroidism have been reported, however, there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The latest American Thyroid Association’s guideline gives support to a higher TSH upper reference range of 4 mIU/l than the one proposed a few years ago of 2.5 mIU/l for the first trimester of pregnancy, in the absence of local normal ranges of TSH. ...